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Clinical Genetics PDF Print E-mail


The central goal in our group is to conduct world standard research projects focused on genetic aspects of reproduction and to apply the results in providing quality services to those couples referred with infertility. In addition, assessment of embryonic/fetal genetic health is of our main focuses. This bi-potential, research/clinical essence, has gathered close collaboration between scientists from the fields of reproductive genetics as well as medical/clinical genetics. Currently our team is engaged in various research projects which are aimed to evaluate the contribution of genetic factors to normal reproduction as well as infertility conditions. The areas of interest include reproduction health and related disorders associated to female, male and idiopathic infertility.
Among conditions with female infertility, our main projects cover areas such as primary ovarian insufficiency (POI), diminished ovarian reserve (DOI), repeated pregnancy loss (RPL) and pregnancy related disorders (such as preeclampsia). With regards to male infertility, sperm anomalies (quantity, morphologic and motility related conditions), varicocele and CBAVD are of great interest. Important areas related to the implantation of embryo and fetal health are also among our research focus, including recurrent implantation failure (RIF) and embryonal/fetal chromosomal/single gene disorders.
In conjunction with research activities, our group has established a multidisciplinary medical genetic laboratory which is equipped with world level infrastructures and is aimed to present high quality diagnostic services to the patients. This multidisciplinary laboratory consists of cytogenetics, molecular genetics and preimplantation genetic diagnosis (PGD) divisions. Each division has provided the full range of genetic tests routinely required for clinical evaluations of affected couples. The range of provided tests are not limited to but include blood karyotype, amniotic cells karyotype, microdeletions of chromosome Y, hereditary thrombophilia, FMR1 CGG repeat analysis, CFTR mutation analysis, rapid assessment of fetal aneuploidies (QF-PCR/MLPA/FISH), preimplantation genetic screening/diagnosis for chromosomal as well as single gene disorders.
Our unit of genetic counselling is another important facility which provides counseling services to infertile couples with a focus on genetic factors related to infertility and to offer them with proper genetic testing. In addition, genetic counselling unit is closely collaborating with research projects by introduction of familial/hereditary cases.

Group Leader
MR Zamanian MD, PhD

Principal investigators
H Gourabi, PhD
MR Zamanian, MD. PhD
Anahita Mohseni Meybodi, PhD
M Bazrgar, PhD
M Totonchi, PhD
SN Almadani, MD
Sh Zar'i Moradi, PhD candidate

Academic Staff
P Borjian, MSc
P Mokhtari, MSc
NS Masoodi, PhD candidate
Z Rokhsat-talab, MSc

Multidisciplinary genetic laboratory staff
F Reihani-Sabet, PhD candidate
J Saffari PhD, candidate
Sh Boloori, MSc

Research areas of interest

  • Yq microdeletions in Iranian infertile men: importance of gene dosage and partial AZFc deletions.
  • Patterns of miRNAs expression among men with varicocele: evaluation of oxidative stress and heat shock pathways.
  • Evaluation of cell free fetal nucleic acids as biomarkers for non-invasive screening of pregnancy related disorders (preeclampsia, GDM)
  • Evaluation of QF-PCR efficacy for detection of aneuploidies in single blastomere biopsies.
  • Evaluation of selected gene polymorphisms in recurrent implantation failure (APO-E, FSHR, FV, PAI-1, MTHFR, …)
  • Genetic alterations involved in sperm maturation process and sperm abnormal morphology and their impact on ART outcome.
  • Investigation the molecular mechanism of ovarian reserve/response and oocyte development.
  • Revealing the mechanisms of preimplantation and prenatal aneuploidies
  • Safely reduction of preimplantation aneuploidies
  • Noninvasive preimplantation genetic analyses using spent media


Recent Publications

  • F. Mohammadpour Lashkari, M. Totonchi , M. R. Zamanian, Z. Mansouri , M. A. Sadighi Gilani, M. Sabbaghian , A. Mohseni Meybodi. 46,XX males: a case series based on clinical and genetics evaluation. Andrologia Andrologia. 2017 Sep;49(7).
  • Ghezelayagh Z, Totonchi M, Zarei-Moradi S, Asadpour O, Maroufizadeh S, Eftekhari-Yazdi P, Gourabi H, Mohseni-Meybodi A. The Impact of Genetic Variation and Gene Expression Level of The Follicle-Stimulating Hormone Receptor on Ovarian Reserve. Cell J. 2018 Jan;19(4):620-626.
  • Moazenchi M, Totonchi M, Salman Yazdi R, Hratian K, Mohseni Meybodi MA, Ahmadi Panah M, Chehrazi M, Mohseni Meybodi A.The impact of Chlamydia trachomatis infection on sperm parameters and male fertility: A comprehensive study. Int J STD AIDS. 2017 Jan 1:956462417735245.
  • Borjian Boroujeni P, Sabbaghian M, Vosough Dizaji A, Zarei Moradi S, Almadani N, Mohammadpour Lashkari F, Zamanian MR, Mohseni Meybodi A. Clinical aspects of infertile 47,XYY patients: a retrospective study. Hum Fertil (Camb). 2017 Jul 18:1-6.
  • Mozdarani H, Ghoraeian P, Mozdarani S, Fallahi P, Mohseni-Meybodi A. High frequency of de novo DAZ microdeletion in sperm nuclei of subfertile men: possible involvement of genome instability in idiopathic male infertility. Hum Fertil (Camb). 2017 May 19:1-9.
  • Hossein Eslami, Ali Eslami, Raha Favaedi, Ummolbanin Asadpour, Shabnam Zari Moradi, Poopak Eftekhari-Yazdi, Tahereh Madani, Maryam Shahhoseini, Anahita Mohseni Meybodi, Epigenetic Aberration of FMR1 Gene in Infertile Women with Diminished Ovarian Reserve. Cell J. Volume 20, Number 1, Spring 2018, Serial Number: 77- Pages:78-83.
  • Farahmand K, Kalantari H, Fakhri M, Fazeli AS, Moradi SZ, Almadani N, Hashemi M, Gourabi H, Mohseni-Meybodi A., (2016), Evaluation of 1100 couples with recurrent pregnancy loss using conventional cytogenetic, PGD, and PGS: hype or hope; Gynecol Endocrinol. Volume 32, 2016 - Issue 6.
  • Ahmadi Rastegar, D; Sharifi Tabar, M; Alikhani, M; Parsamatin, P; Sahraneshin Samani, F; Sabbaghian, M; Sedighi Gilani, M,A; Mohammad Ahadi, A; Mohseni Meybodi, A; Piryaei, A; Ansari-Pour, N; Gourabi, H; Baharvand, H; Salekdeh, Gh. (2015), Isoform Level Gene Expression Profile of Human Y Chromosome Azoospermia Factor Genes and their X Paralogues in the Testicular Tissue of Non-obstructive Azoospermia Patients ; 2015 Sep 4;14(9):3595-605. doi: 10.1021/acs.jproteome.5b00520.
  • Zamanian M, Qader Hamadneh LA, Veerakumarasivam A, Abdul Rahman S, Shohaimi S, Rosli R. Calreticulin mediates an invasive breast cancer phenotype through the transcriptional dysregulation of p53 and MAPK pathways. Cancer Cell International. 2016;16(1):56.
  • Zamanian M, Veerakumarasivam A, Abdullah S, Rosli R. Calreticulin and Cancer. Pathology & Oncology Research. 2013;19(2):149-54.
  • Asadi F, Sadighi Gilani MA, Ghaheri A, Roodgar Saffari J, Zamanian M. The Prevalence of Y Chromosome Microdeletions in Iranian Infertile Men with Azoospermia and Severe Oligospermia. Cell Journal (Yakhteh). 2017;19(1):27-33.
  • Bazrgar M, Gourabi H, Yazdi PE, Vazirinasab H et al. The effect of prolonged culture of human chromosomally abnormal embryos on the rate of diploid cells. Int J Fertil Steril. 2016; 9(4): 563-573. PMID: 26985346.
  • Najafi K, Kariminejad R, Hosseini K, Moshtagh A, Abbassi GM, Sadatian N, Bazrgar M, Kariminejad A, Kariminejad MH. Familial Case of Pelizaeus-Merzbacher Disorder Detected by Oligoarray Comparative Genomic Hybridization: Genotype-to-Phenotype Diagnosis. Case Rep Genet. 2017.  PMID: 28133555.

 

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