Skip to content

Royan Institute

  Home arrow Stem Cell Biology
and Technology
 arrow Bone and Cartilage/Mesenchymal Stem Cells
PDF Print E-mail

Bone and Cartilage/Mesenchymal Stem Cells

Group Leader
Mohammad R. Baghban Eslaminejad, Ph.D
Dr. Mohamad Reza Baghaban Eslaminejad graduated with a degree in Anatomical Sciences from Tarbiat Modarres University in 2004. Since then, he has worked as an academic staff member at Royan Institute, a major center for stem cell research in Iran. In early days of his employment, he established a lab for mesenchymal stem cells (M.SCs) in Royan Institute. The aim of the lab is to pave the way for M.SCs application in reconstructing bone and cartilage defects. To do so, he has published several (about 80) international and national papers on M.SCs. Some of his major achievements include the introduction of a novel method for the purification of murine M.SCs, presenting a novel surface marker for murine M.SCs and the innovation of an efficient method for M.SCs seeding onto bone 3D scaffolds. At the present, his research has reached the clinical trial stage: using M.SCs for human skeletal repair.

Research Assistants
Nesa Fani (M.Sc)
Fatemeh Bagheri (M.Sc)
Sima Bordbar (M.Sc)
Shahrbanoo Jahangir (M.Sc)
Hamid Nazarian (M.Sc)
Forough Azam Sayyahpour (B.Sc)
Leila Taghiar (M.Sc)
Elham Zomorrodian (M.Sc)

Fatemeh Bagheri (Ph.D)
Faa’eze Faghihi (Ph.D)
Mohammad Ghasemzade (Ph.D)
Tahereh Karimi (Ph.D)
Fatemeh Safari (M.Sc)
Mohammad Ali Zaare’ (Ph.D)

The Adult Stem Cell lab focuses on investigating mesenchymal stem cells (M.SCs) with the aim of making it possible to apply M.SCs in the regeneration of bone and cartilage defects in humans. To achieve this goal, the lab has initially designed several researches regarding M.SC basic biology, such as determining an efficient method for their isolation, and optimization of their osteogenic and chondrogenic differentiation. Additionally, some researchers have utilized M.SCs and their regenerative potential in animal models to fabricate bone and cartilage constructs. Additionally, clinical trials regarding bone and cartilage tissue defects are ongoing in collaboration with the Regenerative Medicine Program.

p11 p12
M.SCs loaded on a scaffold 3D pore system

•    Study of the structure of canine mesenchymal stem cell osteogenic culture. Eslaminejad MB, Taghiyar L. Anat Histol Embryol. 2010; 39:446–55.

•    Mesenchymal stem cells from murine amniotic fluid as a model for preclinical investigation. Baghaban Eslaminejad M, Jahangir S, Aghdami N. Arch Iran Med. 2011 Mar;14(2):96-103.

•    Comparison of proliferation and osteoblast differentiation of marrow-derived mesenchymal stem cells on nano- and micro hydroxyapatite contained composite scaffolds. Baghaban Eslaminejad MR, et al. Iranian Journal of Biotechnology, 2010; 8(4)

•    Biocompatibility evaluation of nano-rod hydroxyapatite/gelatin coatedwith nano-Hap as a novel scaffold using mesenchymal stem cells. Baghaban Eslaminejad MR, et al. Journal of Biomedical Materials Research. 2010; 92(A):1244–1255.


Main Menu