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Molecular Systems’ Biology

Group Leader
Ghasem Hosseini Salekdeh, Ph.D
Dr. Salekdeh’s research work focuses on proteome and molecular systems biology. He is a council member of the Asia Oceania Human Proteome Organization (AOHUPO) and member of HUPO education committee. He is Director of the  Human Y Chromosome Proteome Project (an official project of HUPO) and Chair of AOHUPO Embryonic Stem Cell (ESC) Membrane Proteome Initiative (AOHUPO ESC-MPI). On a national level, Dr. Salekdeh is a cofounder of the Iranian Proteomics Society and President-elect of this society since 2004. He is also the Head of the Molecular Systems Biology Department at Royan Institute. He is on a number of editorial boards, including the Proteomics Journal. He has received several awards and honors including, the National Biotechnology Award (2007), National Razi Medical Science Award for Advanced Technologies (2009), the Khwarizmi International Award for Fundamental Research (2010) and Hadavi award from the Iranian Academy of Medical Sciences (2010).  He has published over 50 peer-reviewed international papers and has written a text book on Molecular Markers.

Research Assistants
Mehdi Alikahni (M.Sc)
Ali Fathi (M.Sc)
Javad Ghrahchahi (M.Sc)
Vahid Haj Hosseini (B.Sc)
Seyyed Ahmad Mousavi (B.Sc)
Mostafa Naghavi (B.Sc)
Davood Nasrabadi (M.Sc)
Hasan Rasouli (M.Sc)
Seyed Shahaboddin Mirshahvaladi (B.Sc)
Lida Habibi Rezaii (M.Sc)
Mehdi Sharifi (M.Sc)
Faeze Shekari (M.Sc)
Sarah Tale Ahmad (M.Sc)
Haghighat Vakilian (M.Sc)

Bahareh Adhami (M.Sc)
Babak Arefnejad (Ph.D)        
Faranak Fatahi (M.Sc)
Mahdieh Jadaliha (M.Sc)
Arefeh Jafarian (Ph.D)
Zohreh Jangravi (Ph.D)        
Davood Nasrabadi (Ph.D)
Faeze Shekari (Ph.D)
Meghdad Yeganeh (M.Sc)
Maryam Yousefi (M.Sc)

The Department of Molecular Systems Biology emerged as a result of the new research model to analyze biological complexity and gain an understanding of how biological systems function, rather than the characteristics of isolated parts of a cell or organism. The department is integrating high-throughput “-omics” technologies such as genomics, epigenomics, transcriptomics and proteomics as well as bioinformatics in an interactive and collaborative environment.
Our mission is to apply “-omics” technologies supported by bioinformatics and functional analyses to understand molecular networks and mechanisms controlling embryonic stem cells self-renewal and the differentiation, as well as adult cell reprogramming into induced pluripotent stem cells.

Another goal of our group is to explore Y chromosome mapping and related diseases.

•    Defining pluripotent stem cells through quantitative proteomic analysis. Reiland S, Salekdeh GH, Krijgsveld J.  Expert Rev Proteomics. 2011 Feb;8(1):29-42.

•    Generation of liver disease-specific induced pluripotent stem cells along with efficient differentiation to functional hepatocyte-like cells. Ghodsizadeh A, Taei A, Totonchi M, Seifinejad A, Gourabi H, Pournasr B, Aghdami N, Malekzadeh R, Almadani N, Salekdeh GH, Baharvand H. Stem Cell Rev. 2010 Dec;6(4):622-32.

•    Induced pluripotent stem cells: A new era for hepatology. Asgari S, Pournasr B, Salekdeh GH, Ghodsizadeh A, Ott M, Baharvand H. J Hepatol. 2010 Oct;53(4):738-51.

•    Epigenetic analysis of human embryonic carcinoma cells during retinoic acid-induced neural differentiation. Shahhoseini M, Taei A, Mehrjardi NZ, Salekdeh GH, Baharvand H. Biochem Cell Biol. 2010 Jun;88(3):527-38.

•    Proteome analysis of brain in murine experimental autoimmune encephalomyelitis. Fazeli AS, Nasrabadi D, Sanati MH, Pouya A, Ibrahim SM, Baharvand H, Salekdeh GH. Proteomics. 2010 Aug;10(15):2822-32.

•    The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterisation of the carbonate-washed membrane standard. Peng L, Kapp EA, Fenyö D, Kwon MS, Jiang P, Wu S, Jiang Y, Aguilar MI, Ahmed N, Baker MS, Cai Z, Chen YJ, Van Chi P, Chung MC, He F, Len AC, Liao PC, Nakamura K, Ngai SM, Paik YK, Pan TL, Poon TC, Salekdeh GH, Simpson RJ, Sirdeshmukh R, Srisomsap C, Svasti J, Tyan YC, Dreyer FS, McLauchlan D, Rawson P, Jordan TW. Proteomics. 2010 Nov;10(22):4142-8

•    An efficient and easy-to-use cryopreservation protocol for human ES and iPS cells. Baharvand H, Salekdeh GH, Taei A, Mollamohammadi S. Nat Protoc. 2010;5(3):588-94. Review.

•    Nuclear proteome analysis of monkey embryonic stem cells during differentiation. Nasrabadi D, Larijani MR, Fathi A, Gourabi H, Dizaj AV, Baharvand H, Salekdeh GH. Stem Cell Rev. 2010 Mar;6(1):50-61.

•    Identification of cytoplasmic and membrane-associated complexes in human embryonic stem cells using blue native PAGE. Shekari F, Taei A, Pan TL, Wang PW, Baharvand H, Salekdeh GH. Mol Biosyst. 2011 Jul 5. [Epub ahead of print]

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