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Regenerative Medicine

Group Leader
Nasser Aghdami, MD, Ph.D
nasser.aghdami@royaninstitute.org
Dr-aghdami
Nasser Aghdami received his MD from Urmia University of Medical Sciences in 1998 and his Ph.D in Immunology from Tarbiat Modarres University in 2007. From 2006-2008 he was the Head of the Transplantation Laboratory at Royan institute. From 2008 Since 2008 he is the Head of the Department of Regenerative Medicine and Royan Cell Therapy Center.

 Research Assistants
Leila Arab (MD)
Roghaie Fazeli (MD)
Reza Moghaddasali (M.Sc)
Parvaneh Mohamadi (M.Sc)
Zahra Orouji (MD)
Ehsan Taghi Abadi (B.Sc)
Soura Mardpour (M.Sc)
Ali Reza Goodarzi (M.Sc)
Negar Karimi (M.Sc)

Technical Staff
Fatemeh Vaezi (B.Sc)
Atefeh Shahbazi (B.Sc)
Nasrin Fallah (M.Sc)
Fatemeh Abassi (M.Sc)
Vajiheh Azimian (M.Sc)
Saeedeh Ebrahim Khani (M.Sc)
Mohammad Nezampour (B.Sc)
Mohsen Tofighian (M.Sc)
Elham Yektadoost (B.Sc)

Active Committees in Royan Cell Therapy Center:
Committee of Dermatological Diseases:
Zahra Orouji (MD)
Saeed Shafieeyan (MD)
Mohammad Rezvani (MD)
Hamid Sharifeian (MD)
Committee of Cardiovascular Disorders:
Hossein Ahmadi (MD)
Ghassemi (MD)
Behnam Molavi (MD)
Nasseri (MD)
Mohammad Zafarghandi (MD)
Committee of Orthopedic Disorders:
Abolfazl Aghoushi (MD)
Mohsen Emadedin (MD)
Ramtin Rouhipour (MD)
Committee of Neurological Diseases:
Amiri (MD)
Farzad Ashraafi (MD)
Seyyed Masoud Nabavi (MD)
Shahriar Naffisi (MD)
Nouroozian (MD)
Shahidi (MD)
Alireza Zaali (MD)
Committee of Cord Blood:
Marzieh Ebrahimi (Ph.D)
Committee of Quality Control:
Marzieh Ebrahimi (Ph.D)
Committee of Urological Diseases:
Ashrafi (MD)
Committee of Ophthalmological Disorders:
Baradaran Rafiee (MD)
Committee of Gastroenterological Disorders:
Committee of Teeth and Oral Disorders:

Currently, in medicine we use drugs, hormones, enzymes, vaccines, prosthetic substitution, surgical reconstruction and organ transplantation for regeneration of damaged tissue. These methods are all considered essential, but have their limitations. Side effects, invasion, donor limitation, toxicity and immunologic problems are major challenges in this era. Regenerative medicine is an emerging revolutionary approach in modern medicine as it delivers living tissue, stimulating the body’s own natural healing process by activating the body’s inherent ability to repair and regenerate. Regenerative medicine may help heal broken bones, severe burns, chronic wounds, heart damage, nerve damage and many other diseases. Regenerative medicine is a multidisciplinary field involving biology, medicine and engineering.  
However, to see these methods in the clinicthere is one way, by translation and clinical trials, for the Regenerative Medicine Department at Royan Institute for Stem Cell Biology and Technology, established in 2008, to move along this path. Royan’s first clinical trial was in 2004 with the support of the Small Business Development Center (SBDC) as a breakthrough in application of stem cells on humans. This clinical trial was undertaken on patients with recent myocardial infarction followed by three other clinical trials, all at almost the same time. At the beginning of 2007, the same time as the Institute’s movement to its new facilities, Royan’s Cell Transplantation Laboratory was established as a separate facility. However, increasing the number of clinical trials to ten at the beginning of 2008, and finishing the trial projects in using melanocytes for treatment of vitiligo as well as successful culture and application of limbal stem cells on humans led us to establish the Regenerative Medicine Department at Royan Institute.
Now, we have more than 25 clinical trials in cell therapy. To improve and expand our projects and plans, we have defined different committees which aim to evaluate scientific matters in relation to cell therapy in order to improve the techniques and findings for better applications. These committees aim to create a relation between the clinical and basic science sectors to improve the research and studies conducted..
Below are listed a number of these committees:

1.    Clinical committee of skin diseases
2.    Clinical committee of cardio vascular diseases
3.    Clinical committee of orthopedic diseases
4.    Clinical committee of neurological diseases
5.    Clinical committee of gastrointestinal diseases
6.    Clinical committee of dental and periodontal diseases
7.    Clinical committee of eye diseases
8.    Clinical committee of the digestive system
9.    Clinical committee of nephrology and urinary tract diseases
10.    Scientific committee of cord blood
11.    Quality control committee

Current medical services in the cell therapy center are as follows:
1.    Transplantation of melanocytes for patients with vitiligo
2.    Culture and transplantation of limbal stem cells
3.    Culture and transplantation of fibroblasts
4.    Culture and transplantation of chondrocytes
5.    Transplantation of bone marrow stem cells or mesenchymal stem cells plus TCP to cure bone disorders
6.    Producing fibrin glue for application in surgery.

p14
a. MR image at saggital plane of the same patient depicted in B. showing increased signal intensity due to subchondral edema before stem cell injection. b. 6 months after stem cell injection demonstrating disappearance of signal changes. Arrow`s head shows a slight increase in cartilage thickness.

Publications:
•    Intraepidermal injection of dissociated epidermal cell suspension improves vitiligo. Khodadadi L, Shafieyan S, Sotoudeh M, Dizaj AV, Shahverdi A, Aghdami N, Baharvand H. Arch Dermatol Res. 2010 Oct;302(8):593-9.
•    Safety and efficacy of granulocyte-colony-stimulating factor administration following autologous intramuscular implantation of bone marrow mononuclear cells: A randomized controlled trial in patients with advanced lower limb ischemia. Zafarghandi MR, Ravari H, Aghdami N, Namiri M, Moazzami K, Taghiabadi E, Fazel A, Pournasr B, Farrokhi A, Sharifian RA, Salimi J, Moini M, Baharvand H. Cytotherapy. 2010 Oct;12(6):783-91.

 

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