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Skin Disorders PDF Print E-mail

After providing service for vitiligo and wrinkle patients using injection of cultured melanocytes, keratinocytes and fibroblasts, an important action of this group in 2012 focused on doing clinical trials stage I and II on Epidermolysis Bullosa, burn and also to find new methods to treat vitiligo.
 
skin 1
Mitted hand after surgery and using amniotic membrane autologous cultured fibroblasts

Epidermolysis Bullosa or EB is a genetic disease in which there are defects in several layers of skin, such as epidermis sticking to the dermis. In EB, patients always suffer from massive injuries and pain - even in the mucosal tissue of their body - which are often resistant to treatment. Today, especially in medicine and cell therapy researchers try to create suitable biological coverage to heal pain and wound’s EB patients. To help these patients in a phase I clinical trial, the specialists evaluated the safety and efficacy of usage of fibroblasts cultured on amniotic membrane in healing of refractory ulcers.
The results of this study in 10 patients showed amniotic membrane with cultured cells can improve wound healing better than amniotic membrane without cells and also it can reduce hospital stay and side effects. But as the major problem in these patients is due to genetic defect in their fibroblast cells and not producing collagen, it seems logical to use allogenic fibroblasts instead of one’s own fibroblast. The specialists can isolate allogenic fibroblast from parents’ fibroblast or fetal fibroblast. So phase1 and 2 of clinical trial is planned in collaboration with Hazrate Fatemeh Hospital to use these cells in refractory ulcers. The results of this study suggest that not only this method can heal the wound faster but also it hasn’t any side effect. According to these results, this group intends to plan larger study for EB in collaboration with community health centers, Tehran University of Medical Sciences (Hospital Fatimah Zahra) in the near future.
 
skin 2
Mitted hand after surgery and using amniotic membrane allogeneic cultured fibroblasts
 
This group is following two purposes in stem cell therapy for patients with high-grade skin burns. First, decreasing scar formation following damage and second increasing regeneration in damaged tissue. Therefore, fibroblasts and keratinocytes are transplanted in a controlled phase I trial involving 10 patients. Initial reports showed that although transplantation facilitates regeneration process, but it doesn’t reduce total scar size significantly. It seems that high turnover and fast proliferation should be an important factor for determining regeneration efficacy in skin burns. Therefore, the researchers are conducting a study in which they use fetal fibroblasts derived from amniotic membrane for treatment of skin burns.
 
skin 3
Scar regeneration in patient with old scar because of burn victim after treatment with autologous culture Keratinocyte and Fibroblast

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