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The Genetics Department was established in 2001. Some routine activities of this department include: genetic counseling, lymphocyte karyotyping, preimplantation genetic diagnosis (PGD), as well as molecular diagnostic tests which include the diagnosis of Y chromosomal microdeletions and certain mutations in candidate genes that may be related to the causes of abortions or failed ART.
The major research interests in this department are genetic causes of male and female infertility, recurrent spontaneous abortion (RSA), genetic factors leading to azoospermia, mutations leading to congenital agenesis of the vas deferens, preimplantation genetic diagnosis, pharmacogenetics, and epigenetic and gene expression profiles of early embryogenesis.
The production of recombinant proteins by genetic manipulation in different host cells in addition to the joint production of transgenic animals in a project with the Embryology Group is another main activity of this department.
Activities carried out in collaboration with Royan Institute for Stem Cell research are karyotyping of stem cell lines following various manipulations, epigenetic and genetic studies of stem cells and iPS cells, in addition to other common research interests.
 
Goals of the Department
  • To improve implantation rates and health of embryos by preimplantation genetic screening and diagnosis
  • To assist physicians with prescribing medicine for controlled ovarian stimulation via pharmacogenetics
  • Genetic follow up of newborns conceived by ART
  • Evaluation of candidate genes related to recurrent abortion in the Iranian population
  • Epigenetic studies of oocytes, sperm and embryos
 
The mission of the Genetics Department is basic research on genetic and epigenetic factors that may influence fertility, embryo development and implantation, bringing these research results to the clinical setting with the purpose of improving the health of patients and newborns, as well as the production of pharmaceutical proteins through transgenic animals.
 
The vision of this department is to perfect diagnosis and treatment of infertility based on reproductive genetics knowledge, which will lead to healthy newborns in a short period of time.
 
 

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