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Japanese Stem-Cell Scientist Yoshiki Sasai Commits Suicide PDF Print E-mail
Aug 06, 2014 at 12:16 PM
TOKYO—A top Japanese scientist who co-authored disputed stem-cell papers committed suicide by hanging himself, police said Tuesday.
Yoshiki Sasai, deputy director of the Riken Center for Developmental Biology, guided research published in the journal Nature that purported to show a revolutionary method of creating stem cells by dipping cells in a mild acid solution. The research, published in January, was quickly challenged. Nature retracted the papers in July, saying they contained inaccurate data and other flaws that undermined their conclusions.

Scientists Find Protein that Unites Sperm and Egg PDF Print E-mail
Apr 23, 2014 at 08:32 AM
Scientists have identified a long-sought fertility protein that allows sperm to dock to the surface of an egg. The finding, an important step in understanding the process that enables conception, could eventually spawn new forms of birth control and treatments for infertility.
“It’s very important, because we now know two of the proteins that are responsible for the binding of sperm to the egg,” says Paul Wassarman, a biochemist and developmental biologist at the Icahn School of Medicine at Mount Sinai in New York.

sperm and egg

Iran at Forefront of Stem Cell Research PDF Print E-mail
Aug 13, 2013 at 04:30 AM
Though the world’s attention has focused on Iran‘s advancing nuclear program, Iranian scientists have moved to the forefront in embryonic stem cell research, according to a recent joint study by Harvard University and the Massachusetts Institute of Technology.
Controversial in the United States, embryonic stem cell research was embraced in 2002 by Ayatollah Ali Khamenei, Iran’s conservative religious leader. President Obama has recently adopted a similar policy, reversing restrictions that George W. Bush’s administration imposed because of the implications for destroying potential human lives.
Stem Cells Reprogrammed Using Chemicals Alone PDF Print E-mail
Jul 21, 2013 at 04:40 AM

Patient-specific cells could be made without genetic manipulation.

Scientists have demonstrated a new way to reprogram adult tissue to become cells as versatile as embryonic stem cells — without the addition of extra genes that could increase the risk of dangerous mutations or cancer.
Researchers have been striving to achieve this since 2006, when the creation of so-called induced pluripotent (iPS) cells was first reported. Previously, they had managed to reduce the number of genes needed using small-molecule chemical compounds, but those attempts always required at least one gene, Oct4.
Now, writing in Science, researchers report success in creating iPS cells using chemical compounds only — what they call CiPS cells.

hires reduced

Turning human cells into stem cells without changing their genes could lead to therapies that do not carry a risk of generating mutations.

Next-Gen Test Tube Baby Born PDF Print E-mail
Jul 13, 2013 at 09:34 AM

A baby has been born using in vitro fertilization aided by next-generation sequencing of embryos for genetic abnormalities.

Abnormalities in the DNA of embryos account for the two-thirds failure rate of in vitro fertilization (IVF)—a procedure where eggs are fertilized by sperm in a dish, then later implanted in the uterus. Genetic tests exist to screen for embryos with chromosomal or genetic defects prior to implantation, but the tests are expensive and have drawbacks. Researchers at the University of Oxford have developed a relatively inexpensive next-generation sequencing technique that overcomes the limitations of previous tests, and has already been used in the IVF procedure that resulted in the birth of a baby boy in May. The research was reported Monday (July 8) at the annual meeting of the European Society of Human Reproduction and Embryology in London.

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