Skip to content

Royan Institute

  Home arrow Reproductive
 arrow Genetic Engineering
Genetic Engineering PDF Print E-mail

Biotechnology is a field of applied biology that involves the use of living organisms and bioprocesses in engineering, technology, medicine and other fields requiring bioproducts. Biotechnology also utilizes these products for manufacturing purposes. Modern use of similar terms includes genetic engineering as well as cell- and tissue culture technologies. The concept encompasses a wide range of procedures (and history) for modifying living organisms according to human purposes-going back to domestication of animals, cultivation of plants and “improvements” to these through breeding programs that employ artificial selection and hybridization. By comparison to biotechnology, bioengineering is generally thought of as a related field with its emphasis more on higher systems approaches (not necessarily directly altering or using biological materials) for interfacing with and utilizing living things. Biotechnology draws on the pure biological sciences (genetics, microbiology, animal cell culture, molecular biology, biochemistry, embryology, cell biology) and in many instances is also dependent on knowledge and methods from outside the sphere of biology (chemical engineering, bioprocess engineering, information technology, biorobotics). Conversely, modern biological sciences (including concepts such as molecular ecology) are intimately entwined and dependent on the methods developed through biotechnology and what is commonly thought of as the life sciences industry. Modern biotechnology is often associated with the use of genetically altered microorganisms for the production of substances. It can also refer to transgenic animals genetically altered mammalian cells, such as Chinese hamster ovary cells (CHO), are also used to manufacture certain pharmaceuticals.

Group Leader
Mohammad H Sanati, PhD

Scientific staff
Hamid Gourabi, PhD
Amir Amiri-Yekta, PhD

Research Assistants
S. Abolghasemi, PhD student
A. Daneshipour, MSc
N. Fatemi, PhD student
Z. Halfinezhad, MSc
H. Javid, PhD
F. Norouzi, MSc 


S. Bahrami (PhD student, Molecular Genetics)
M. Bayat (PhD student, Molecular Genetics)
S.H. Jazayeri (PhD student, Medical Biotechnology)       
S. Mirzaei (PhD student, Molecular-Cellular Biology)

Ongoing Projects

  • Production of pharmaceutical recombinant proteins in eggs using sperm mediated gene transfer for production of transgenic hens.
  • Utilization of self-amplifying and Cre-loxP systems in production of transgenic chicken expressing Human Serum Albumin in egg white.
  • Sperm mediate gene transfer in rooster for in vitro production of transgenic chicken, combining effect of lipofection and dimethyl solfoxyde.    
  • Production of transgenic chicken with the ability of anti-cd34 antibody gene expression in oviduct.
  • Production of recombinant human and animal fertility hormones (FSH, LH and HCG).
  • Preparation and characterization of sustained release in situ forming drug delivery systems containing growth hormone base on PLGA polymer (in-vitro and in-vivo evaluation).
Recent Publications (2017)

  • Jazayeri SH, Amiri-Yekta A, Gourabi H, Abd Emami B, Halfinezhad Z, Abolghasemi S, Fatemi N, Daneshipour A, Ghahremani MH, Sanati MH, Khorramizadeh MR. Comparative Assessment on the Expression Level of Recombinant Human Follicle-Stimulating Hormone (FSH) in Serum-Containing Versus Protein-Free Culture Media. Mol Biotechnol 2017, DOI 10.1007/s12033-017-0037-4.

  • Jazayeri SH, Amiri-Yekta A, Bahrami S, Gourabi H, Sanati MH, Khorramizadeh MR. Vector and Cell Line Engineering Technogies Toward Recombinant Protein Expression in Mammalian Cell Lines.  Applied Biochem Biotechnol 2017.

Main Menu