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Embryonic Stem Cell Biology
Adeleh Taee (Microbiology BSc)
Sepideh Mollamohammadi (Microbiology BSc)
Mohammad Pakzad (Biology BSc)
Embryonic stem cells (ESCs) are undifferentiated cells, which are typically derived from the inner cell mass of a blastocyst-stage embryo. In culture, these cells have the capacity to self-renew in an undifferentiated state but also may differentiate into cell types representing the three embryonic germ lineages, thus revealing their pluripotent potential. These cells could be of value for creating in-vitro culture systems and animal models that may be used to study human genetic disease, gene function, drug discovery, developmental biology, and differentiation events.
Embryonic Stem Cell Biology as the first group of stem cell department  established in 2003 to derive and maintain embryonic stem cell lines focusing on ESCs characteristics determination as well as culture condition  improvement and up to now 8 murine and 6 human embryonic stem cell lines have been harvested.

The main goal of this group is to achieve applicative approaches for the derivation, maintenance, and safety of human ESCs in regenerative medicine.

Royan Stem Cell Lines:
Five Mouse  Embryonic  Stem Cell lines  in Collaboration with Australia, 3 Mouse Embryonic Stem Cell Lines supported by Molecular Medicine Network (Iran Pastur Institute), and 6 human Embryonic Stem Cell Lines have been established in this group. One hESC line (Royan H1) has been registered in International Society for Stem Cell Research (ISSCR).

To see Royan Stem Cell lines characteristics click here.

Characterizations of Royan hESC lines 


Development, Growth and Differentiation,2006, 48, 323-332

Differentiation, 2004 Jun;72(5):224-9




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